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Hahn, L. , Bailey, L. , Dupont, W. , Parl, F. , and Moore, J. H. (2001). Multifactor-dimensionality reduction reveals high-order interactions among estrogenmetabolism genes in sporadic breast cancer. Am. J. Hum. Genet. 69, 138–147. Ritchie, M. , Hahn, L. , and Moore, J. H. (2003). Power of multifactor dimensionality reduction for detecting gene–gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet. Epidemiol. 24, 150–157. , Hauser, E.
3. Alternate an operator. An OR is replaced by an AND, or vice versa. Grow a branch. , the leaves), a new branch can be grown by cutting the subtree starting at this node, adding a new operator to this node, and adding the subtree to the right branch and a leaf to the left branch of this new node. In Fig. 3, for example, the subtree S1D ^ S2DC is cut from the left-most tree, and an OR is added to the corresponding node. Then, S4R and S1D ^ S2DC are added as the children to this node to generate the tree in the upper middle of Fig.
Bioinformatics 20, 2799–2811. , Gelatt, C. D. , and Vecchi, M. P. (1983). Optimization by simulated annealing. Science 220, 671–680. , and Ruczinski, I. (2005). Identifying interacting SNPs using Monte Carlo logic regression. Genet. Epidemiol.
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